RB Jordan Mason filled in admirably to start the year, but he was hit with a shoulder injury in Week 6 that he battled until McCaffrey’s return in Week 10. McCaffrey and Mason were both hurt in a Week 13 loss to the Buffalo Bills, which pushed rookie fourth-round pick RB Isaac Guerendo into the starting role.

The San Francisco 49ers are going to have a fourth different starting running back this season according to a report from ESPN’s Adam Schefter. Running back Isaac Guerendo suffered a

Guerendo has rushed for 381 yards and four touchdowns this season. The 49ers are also likely to again be without left tackle Trent Williams as well Sunday. Williams has missed the