The Bills will be trying to end a two-game losing streak when they play the Panthers Sunday. Here's the broadcast and betting information.

The Bills have the Chiefs' number in regular-season play. They are 5-1 against Kansas City in regular-season meetings since 2017 and won each of the last four matchups. It is when the stakes are at their highest that the Chiefs take control. They won each of the four playoff showdowns since Mahomes and Allen joined their respective teams.

One of the most highly anticipated matchups of the season is next up, featuring the Bills and Chiefs. Quarterbacks Patrick Mahomes and Josh Allen make for some must-see television, with Allen rising to the occasion in some of the best games of his career against the Chiefs.

A member of the Bills from 1969 through 1977, Simpson is second in franchise history with 10,183 yards. He was surpassed by Thurman Thomas, who recorded 11,938 yards in his historic career. Thomas is also one of the backs to cross 200 in a game, racking up 214 in 1990 against the New York Jets.

Isiah Pacheco is out for the Kansas City Chiefs, and the team has activated Clyde Edwards-Helaire for the game against the Bills.

The Bills will have both Matt Milano and Terrel Bernard back, but another linebacker will not play against the Chiefs.

The Buffalo Bills had another key member of their defense miss time, with one of their linebackers sitting out of Thursday's practice.