Despite warnings, potentially inappropriate CNS-active medications are commonly prescribed to older adults — especially those with cognitive impairment — highlighting missed opportunities for safer ...

Nanocarriers for CNS drugs offer many benefits that can aid increased delivery to the brain. As drugs circulate throughout the body, they encounter blood proteins and enzymes that may result in ...

Despite new methodologies and flexible regulatory pathways, CNS biopharmaceuticals still face significant safety assessment ...

Questionable prescribing of CNS-active drugs persists ...

Sage Therapeutics has been working in the area of steroid-derived compounds that affect CNS receptor signaling. A pivotal trial failed to show benefit, and they had several other clinical failures as ...

This episode of the Pharmaron DMPK Insights Podcast Series sees Scott Summerfield (Senior Director and Head of Pharmaceutical Metabolism at Pharmaron) and Professor Elizabeth de Lange Professor in ...

Partnership launched under MTEA to evaluate the potential of Vect-Horus technology to deliver siRNAs into the CNSAssessment ...

TRPML1 is a promising target1 for Parkinson’s disease treatments and identifying translational biomarkers will help confirm target engagement ...

Seatbelts save lives”? This public service announcement became popular in the 1980s. It helped increase the use of seatbelts in private vehicles. By the mid-1990s, most states required their use by ...

Industry-Leading Platform Achieves 94% Accuracy with Real-Time Machine Learning, Providing Open-Access to Critical CNS Drug Development Technology Additional Predictive, Analytic and Descriptive ...