How cells 'back up' DNA replication to survive severe damage

Every time a cell divides, it must copy its DNA with extraordinary precision. But this process is constantly challenged by DNA damage. Among the most dangerous lesions are DNA interstrand crosslinks ...
ucdavis.edu

Computational Model Uses Language Theory to Predict DNA Shapes That Underlie Gene Expression and Disease

R-loops are structures that form when a strand of RNA (red) forms a stable structure with double-stranded DNA, causing one strand of the DNA to form a loop. R-loops are associated with gene ...
Tech Times

Wisconsin Researchers Map Bacterial DNA Repair Restart, Revealing New Antibiotic Targets

Structural biologists at the University of Wisconsin-Madison today published cryo-electron microscopy structures of the complete bacterial DNA replication restart complex — a molecular machine that le ...
Medical Xpress

Comparing DNA language models to guide optimal AI selection for genomics

Researchers at The University of Texas MD Anderson Cancer Center have performed a comprehensive evaluation of five artificial intelligence (AI) models trained on genomic sequences, known as DNA ...
Kaleido Scope

New model for replication of BKPyV virus, a major cause of kidney transplant failure

To better understand BKPyV replication and ways to prevent it, researchers in the UAB Department of Microbiology have published a single-cell analysis of BKPyV infection in primary kidney cells. Their ...