The cell cytoskeleton is modulated by motor proteins, known as dyneins, that generate force and movement on microtubules to control a wealth of biological processes, including motility, cell division, ...

The most lethal feature of any cancer is metastasis, the spread of cancer cells throughout the body. New research reveals the mechanics behind how breast cancer cells may invade healthy tissues. The ...

Researchers have uncovered the mechanism by which a protein facilitates the spread of breast cancer cells from the primary tumor into healthy tissue. The discovery not only improves our understanding ...

Salk Institute and UC San Diego researchers capture first-of-its-kind video of dynein-Lis1 protein interaction, supporting future drug development for neurological disorders LA JOLLA (May 23, ...

A mechanism of dynein-powered metastatic locomotion has been identified using soft tissue models, revealing a new clinical target for breast cancer treatment. New research led by Penn State (PA, USA) ...

Dyneins are eukaryotic force-generating ATPases responsible for movement along microtubules, driving the beating of cilia and flagella, and key cytoplasmic processes, such as intracellular transport ...

A human breast cancer cell, adenocarcinoma MDA-MB-231, demonstrates metastatic-like adhesion, spreading and migrating in a collagen matrix designed to mimic soft tissue. New research led by Penn State ...