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Week 2 NFL Predictions: Picks and score predictions for primetime matchups

After a jam-packed Week 1, which teams are going to get wins in primetime matchups for Week 2 of the 2025 NFL season? We make our picks and score predictions.
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Lions vs. Bills Week 2 matchup listed as highest-priced NFL ticket

As the 2026 NFL season approaches, the Week 2 "Thursday Night Football" clash on Sept. 17 between the Detroit Lions and Buffalo Bills from the new Highmark Stadium ranks as the league's highest-priced ...