Meiotic recombination is a specialised process in which programmed DNA double-strand breaks initiate the exchange of genetic material between homologous chromosomes. This exchange forms crossovers ...

Keeping the genetic information stored in genomic DNA intact during the cell division cycle is crucial for almost all lifeforms. Extensive DNA damage invariably causes various adverse genomic ...

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF.

Within every cell in our body, our DNA is tightly bundled with proteins to form structures known as chromosomes. The commonly known shape of a chromosome relates to an X-shaped appearance in many ...

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic ...

In the 1980s, scientists knew little about the X and Y chromosomes. What they did understand was that every cell in the body contains 23 pairs of chromosomes. Each of these pairs is similar, except ...

Scientists have discovered an association between a variant in the synaptonemal complex protein, SYCE2, and pregnancy loss through the effects of recombination. An international collaboration led by ...

Early in the development of sperm, a strange event happens: the X and Y chromosomes condense into tight packages and are sequestered away from the other 44 human chromosomes. If any part of this ...

The above representative microscope images showcase ultra-fine bridges, a kind of abnormal link between chromosomes that causes catastrophic genetic instability. These bridges, composed of entangled ...