Waltham, MA–based biotech Mural Oncology announced that it will end its phase III trial of nemvaleukin alfa, an engineered fusion protein that selectively binds to the intermediate-affinity IL2 ...

1Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York. 2Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, ...

The acting director of the Centers for Disease Control and Prevention (CDC), Susan Monarez, PhD, has been nominated to lead the agency. Prior to moving to the CDC in January, Monarez, who’s held ...

Boston, MA–based Dana-Farber Cancer Institute (DFCI) secured approval from the state to build a 300-bed hospital at the current site of the Joslin Diabetes Center in the city’s Longwood Medical Area.

Major Finding: EMT-associated genomic instability promotes tumor heterogeneity and aggressive clinical behavior. Concept: Mesenchymal cells exhibit increased chromatin accessibility that leads to ...

Major Finding: Macrophage migration inhibitory factor (MIF), secreted by tumor cells, hinders adipogenesis in cancer cachexia. Concept: Signaling from tumor cells to adipose stem and progenitor cells ...

Main Finding: Tumor cells secrete an aminopeptidase that frees amino acids for uptake by neighboring cells, enhancing overall tumor fitness. Concept: Nutrient scavenging, driven by secreted CNDP2, is ...

A new study in mice shows that COX-1 inhibitors, such as aspirin, block a platelet-mediated pathway that cancer cells use to evade immune detection and spread to other tissues. By reducing TXA2 ...

Major Finding: Fragmentomics analysis of Epstein-Barr virus DNA in plasma predicts risk of nasopharyngeal carcinoma. Concept: The quantity, size distribution, methylation patterns, and end motifs of ...

Menlo Park, CA–based Orca Bio announced that its allogeneic T-cell immunotherapy Orca-T led to a significant improvement in survival without chronic graft-versus-host disease (cGvHD) compared with a ...

The NCI–Cancer Research UK initiative Cancer Grand Challenges has once again set out a range of topics for international, multidisciplinary teams of researchers to probe. Teams selected for an award ...