Objectives Blood cultures are the first-line tool for diagnosis of bloodstream infections. Their diagnostic value, however, may be affected when a microorganism of questionable evidence is isolated.

Background: Difficulty falling asleep (prolonged sleep latency) is a frequently reported problem in school-aged children. Aims: This study aimed to describe the distribution of sleep latency and ...

Research on distress and coping provides theoretical and practical information on treatment. Cognitive and behavioural coping with illness itself or a specific treatment affect adjustment in the ...

Objective Impaired fetal and infant growth may cause alterations in developmental programming of the hypothalamic–pituitary–gonadal axis and subsequently pubertal development. We aimed to assess ...

Attention deficit hyperactivity disorder (ADHD) affects around 1–3% of children. There is a high level of comorbidity with developmental and learning problems as well as with a variety of psychiatric ...

SMA is a motor neuron disease characterised by generalised muscle atrophy and weakness. It is caused by the dysfunction and eventual death of motor neurons, due to deletions of SMN1 in 95% of patients ...

Objectives To investigate whether nebulised hypertonic saline (HS) treatment would decrease length of hospital stay (LOS) among infants with moderate-to severe-bronchiolitis compared with standard ...

Objective To investigate a possible association between fever admissions and 4 component Meningococcal B (4CMenB). Design 4CMenB is given at 8 and 16 weeks in the first year of life. Self-controlled ...

Purpose Children with Trisomy 21 are at increased risk of death compared to age-matched controls. We recently undertook a retrospective review of mortality in Trisomy 21 in our tertiary non-cardiac ...

Introduction Global developmental delay (GDD) affects 1%–3% of the population of children under 5 years of age, making it one of the most common conditions presenting in paediatric clinics; causes are ...

Background Mental health problems are prevalent in children and young people (CYP). Children with neurodevelopmental disorders such as ASD have co-morbid mental health difficulties which add to the ...

Objectives One in three children in England have Special Educational Needs (SEN) indicated at least once during school. We describe variation across neurodevelopmental conditions and in unaffected ...