Patrick Dempsey starred in Can’t Buy Me Love (1987) and Loverboy (1989) but is best known as Dr. Derek Shepherd on Grey’s Anatomy, a role he held from 2005 to 2015.

Patrick Dempsey is an American actor. He is best known for his role as Derek "McDreamy" Shepherd on ABC's Grey's Anatomy (2005-2015, 2020-2021). He has also appeared in Sweet Home Alabama (2002 ...