DNL343 and fosigotifator are made to activate the ISR pathway protein eIF2B, but both failed to slow ALS progression in the HEALEY trial.

Shares of Sana Biotechnology Inc. (NASDAQ: SANA) were trading at $4.97, up $3.32, or 201%, on first results from an investigator-sponsored, first-in-human study transplanting UP-421, an allogeneic ...

Tenvie Therapeutics is making hay from an R&D shift at Denali Therapeutics, acquiring several of its neuroscience drug ...

Tenvie Therapeutics has unveiled with $200 million and the goal of transforming the neurological treatment landscape, nabbing ...

In studies by Massachusetts General Hospital, the AbbVie-Calico collaborative drug and Denali Therapeutics' own drug failed to meet endpoints for treating amyotrophic lateral sclerosis, more widely ...

A study of human brain organoids suggested a complex relationship between herpes simplex virus 1 infection and tau, ...

The company said Monday that fosigotifator failed to outperform placebo in slowing the neurodegenerative disease, but is ...

AbbVie, Calico and Denali Therapeutics’ hopes of treating amyotrophic lateral sclerosis (ALS) by targeting eIF2B have all ...

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the ...

The GMC Yukon Denali is a full-size SUV. Read more General Motors reviews to learn about other models. How do I know I can trust these reviews about GMC Yukon Denali? How do I know I can trust ...

President-elect Donald Trump has once again suggested he wants to revert the name of North America's tallest mountain -- Alaska's Denali -- to Mount McKinley, wading into a sensitive and decades ...

President-elect Trump pledged this week to undo former President Obama’s 2015 decision to change the name of North America’s tallest peak to its Koyukon Athabascan name "Denali," meaning "High ...