The San Francisco 49ers entered their Week 18 finale on the road against the Arizona Cardinals with several starters ruled out. Quarterback Brock Purdy, receiver Deebo Samuel and cornerback Deommodore Lenoir were all ruled out with injuries.

The wide receiver took a few knocks in the defeat to the Lions on New Year’s Eve. He missed all of the Niners' practices last week.

Wide receiver Deebo Samuel, quarterback Brock Purdy and cornerback Deommodore Lenoir are all listed as ‘out’ for the team’s Week 18 matchup with the Arizona Cardinals. Tight end George Kittle is also ‘questionable.’

San Francisco 49ers wide receiver Deebo Samuel is officially listed as ‘out’ on the team’s Week 18 injury report, meaning his four-touch, 17-yard, one-touchdown performance against the Detroit Lions in Week 17 could be his last in red and gold.

The San Francisco 49ers entered the 2024 season with high hopes, aiming to bounce back after their second Super Bowl loss during the Kyle Shanahan

The 49ers will wrap up a massively disappointing season without a number of starters when they face the Cardinals in Week 18.

The San Francisco 49ers opened the week with 11 players not practicing and that number was reduced to six on Friday with those players either out or doubtful.

This post is not a referendum on whether 49ers quarterback Brock Purdy is good. There’s nothing more tiresome than an “Is X QB actually good?” argument, especially one that centers around a tiny-ass white dude who was only drafted by the skin of his teeth.

The San Francisco 49ers officially ruled out QB Brock Purdy from Week 18 due to an elbow injury, per Nick Wagoner. San Francisco also ruled out WR Deebo Samuel (ribs, wrist), OL Spencer Burford (calf),