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IV acyclovir; 10 mg/kg body weight every 8 hours. Children up to 11 years and neonates are treated with higher doses (15-20 mg/kg body weight). Acyclovir resistance can arise due to viral deoxypyrimidine kinase or DNA polymerase alterations. So far, acyclovir-resistant strains have not been a significant concern in immunocompetent individuals. Resistance to acyclovir is significantly higher in immunocompromised patients when compared with immunocompetent persons. Acyclovir resistance is usually
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